The effects of cannabinoids vary from person to person, so we recommend using extreme caution when using Doobie Juice Medicated E-Liquid for the first time. For first-time users, do not use more than 4 drops at a time. Here's what we recommend (you can adjust to your own preferences from there). Using Doobie Juice Medicated E-Liquid on an APV or e-cig: Drip enough Doobie Juice to saturate the cotton or wick and take 3-4 good hits. Wait 15-20 minutes to monitor the effects of the medication. Keep the cotton saturated and take additional hits as needed. Using Doobie Juice Medicated E-Liquid as a tincture (orally): Place 2-3 drops under the tongue and allow it to absorb into the body through the soft tissue surrounding the lingual frenulum. It's safe to swallow and will have an effect if swallowed, but some patients are not fans of the flavor when swallowed. Wait 10-15 minutes to monitor the effects of the medication. Use more drops as needed to achieve the desired effect.